Prescription Weight Loss Drugs vs. Commercial Programs
By Omni Patel, SOP Cohort 4 Student
[Omni Patel was nominated by Dr. Tiffany Nguyen to be recognized in the Trinium for this outstanding essay. Ed.]
At a time when more people are seeking help with weight management or looking for a
shortcut to losing weight, new research sheds light on how prescription weight loss
medications compare to popular commercial diet programs. These findings help
individuals make better-informed decisions about which route is best for their health.
The focus is on two articles: one analyzing clinical trials of prescription medications and
the other evaluating a digital diet program. The articles revealed that while both
approaches help people lose weight, their effectiveness and risks differ significantly.
Prescription Medications Lead in Weight Loss, a study published in eClinicalMedicine
reviewed over 150 clinical trials with more than 100,000 participants. Researchers found
that the newest prescription medications, particularly tirzepatide (Zepbound) and
semaglutide (Wegovy), led to the greatest weight loss. People taking tirzepatide lost an
average of about 25 pounds, or 16% of their body weight. Semaglutide helped users
lose about 19 pounds, or 10% of their body weight. These drugs also improved heart
health markers, such as blood pressure and cholesterol. However, they come with side
effects. Some users experienced nausea, increased anxiety, trouble sleeping, or raised
blood pressure, depending on the medication. All drugs were found to be safe overall
when monitored by healthcare professionals.
In comparison, Commercial Programs Still Show Results, is a study published in the
Journal of Medical Internet Research that followed over 24,000 people who enrolled in
the CSIRO Total Wellbeing Diet Online, a digital weight loss program in Australia. After
one year, participants lost an average of 12 to 14 pounds, or around 6% of their
starting body weight. Over half the users lost at least 5% of their body weight, and
about one in four lost 10% or more. Those who used the platform more often saw the
best results. Unlike medications, the commercial program had no reported medical side
effects.
Which One Is Better?
Prescription medications tend to offer more dramatic weight loss, especially for people
who are obese or have health problems like diabetes or high blood pressure. However,
they are more expensive, require a doctor’s prescription, and come with the possibility
of side effects. On the other hand, commercial diet programs are safer and more
accessible to the average person. They can be effective, especially for those who stay
consistent and disciplined.
Ultimately, the best weight loss approach depends on your individual health needs. If
you have obesity-related medical conditions, prescription medications may offer the
most benefit. However, a commercial weight loss program could be a suitable starting
point if you prefer a structured and lower-risk option. Consult your pharmacist or
healthcare provider before beginning any weight loss plan to ensure it aligns with your
health goals.
Resources:
Gilly A Hendrie, Danielle L Baird, Genevieve James-Martin, Emily Brindal, Paige G
Brooker. Originally published in the Journal of Medical Internet Research
(https://www.jmir.org), 15.01.2025.
Safety and effects of anti-obesity medications on weight loss, cardiometabolic, and
psychological outcomes in people living with overweight or obesity: a
systematic review and meta-analysis Liu, Leiling et al. eClinicalMedicine,
Volume 79, 10302
